IndraLab

Statements

Poly I:C inhibits IRF3. 5 / 5
| 5
reach
"Consistently, poly I : C induced IRF-3 dimerization was strongly impaired in NOX2 RNAi vs CTRL RNAi transfected cells (XREF_FIG)."
20532218
reach
"However, LY294002 has recently been shown to inhibit poly I : C induced IRF3 activation by an unknown, PI3K- independent mechanism [XREF_BIBR]."
23892079
reach
"Similarly, C272R mutant did not suppressed poly I : C induced IRF-3 nuclear translocation and interact with MDA5."
21071089
reach
"Mian et al. also observed that smoke conditioned media significantly suppressed the activation of NFkappaB and IRF-3 in nonsmokers ' PBMCs treated with poly I : C [XREF_BIBR], while cigarette smoke extract was shown to dramatically elevate the DNA binding activity of AP-1 rather than NFkappaB in endothelial cells of human umbilical core vein [XREF_BIBR]."
27902485
reach
"Our data on MyD88 corroborates with these observations where poly I:C stimulation downregulated p65 (S536) and pIRF3 (S386), leading to the downregulation of CXCL1 and TNF when compared to wild-type mice."
32824595