IndraLab

Statements

USP25 inhibits TRAF6. 4 / 6
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"Several studies showed that USP25 negatively regulates virus-induced type I IFN signaling by stabilizing TRAF2, TRAF3 and TRAF6 [64,65,75,87,121,122,123,124]."
32650621
reach
"Zhong et al35 reported that USP25 negatively regulates the IL-17-mediated signaling by regulating the K63 modification of TRAF5 and TRAF6 in experimental autoimmune encephalomyelitis."
39619140
eidos
"] USP25 interacts with TRAF3 and TRAF6 following RNA virus or DNA virus infection and prevents TRAF3 and TRAF6 from proteasomal degradation via deubiquitinating K48-linked polyubiquitin chains ."
33511009
reach
"A20 and USP25 downregulate TRAF6, limiting NF-kappaB and MAPK activation."
26320658