IndraLab

Statements


USP25 inhibits TRAF6. 3 / 5
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reach
"A20 and USP25 downregulate TRAF6, limiting NF-kappaB and MAPK activation."

eidos
"] USP25 interacts with TRAF3 and TRAF6 following RNA virus or DNA virus infection and prevents TRAF3 and TRAF6 from proteasomal degradation via deubiquitinating K48-linked polyubiquitin chains ."

reach
"Several studies showed that USP25 negatively regulates virus-induced type I IFN signaling by stabilizing TRAF2, TRAF3 and TRAF6 [64,65,75,87,121,122,123,124]."