IndraLab

Statements

USP9X inhibits VHL. 9 / 9
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"This mechanism of regulation has been already described for USP9X, which downregulates the protein pVHL through its substrate Smurf1, an E3 Ubiquitin ligase that targets pVHL [41]."
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"Previous results demonstrated USP9X decreases the protein stability of pVHL, raising a question as to how USP9X destabilizes pVHL."
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"USP9X negatively regulates pVHL."
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"USP9X knockdown up-regulated pVHL, while HUWE1 showed no evidence of pVHL regulation at the protein level (XREF_SUPPLEMENTARY)."
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"Smurf1 thus mediates downregulation of pVHL by USP9X."
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"In order to demonstrate USP9X negatively regulates pVHL in clear cell renal cell carcinoma (ccRCC) which is a VHL disease associated neoplasm, USP9X was knocked down in 786-0 cells stably expressing HA tagged pVHL."
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"Our findings show pVHL is induced by USP9X knockdown, raising the possibility a suitable USP9X inhibitor may exert a similar effect."
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"USP9X down-regulates pVHL through Smurf1."
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"USP9X degrades pVHL through protection of its substrate, the newly identified pVHL E3 ligase Smurf1."
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