IndraLab

Statements


AKT inhibits USP22. 3 / 3
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"USP22 knockdown enhanced chemosensitivity of hepatocellular carcinoma cells to 5-Fu by up-regulation of Smad4 and suppression of Akt."

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"Silencing Smad4 blocked USP22 knockdown-induced Akt inhibition in Bel/Fu cells."

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"These results suggest that USP22 knockdown induced chemosensitivity of HCC cells by down-regualting PI3K and Akt, and Smad4 mediated Akt suppression as well."