IndraLab

Statements

ASXL binds BAP1. 8 / 8
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"Although H2Aub was previously involved in cell proliferation , it is not clear, at this time, whether the observed effects of ASXL2/BAP1 defective in monoubiquitination are solely due to disruption of H2A deubiquitination or the effect of BAP1/ASXL complexes on other substrates.Our data suggest that the signaling pathway we characterized here is important for tumor suppression."
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"This was in congruence with the fact that BAP1 binds to ASXL to form the Polycomb repressive deubiquitinase complex (PR-DUB) that deubiquitinates histone H2A [XREF_BIBR]."
31208841
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"BAP1 serves a key role in stabilizing epigenetic regulators, including O-linked N-acetylglucosamine (GlcNAc) transferase, host cell factor C1 and ASXL1, and thus an ASXL/BAP1 complex may inhibit chronic myelomonocytic leukemia, in which ASXL1 is frequently mutated (53)."
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"To be noticed, both leukemias and UMs associated with MBD4 inactivation share a consistent inactivation of the BAP1 and ASXL complex."
32239153
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"Our data raise the possibility that ASXL1 truncation mutations confer gain-of-function on the ASXL and BAP1 complex."
26095772
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"Human ASXL1 is mutated frequently in chronic myelomonocytic leukemia (CMML) so an ASXL and BAP1 complex may suppress CMML."
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"BAP1 and ASXL complex modulation regulates epithelial-mesenchymal transition during trophoblast differentiation and invasion."
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"The EMT is associated with upregulation of BAP1/ASXL complex modulation [9] , expression of TGFB1, as well as expression of PAPPA and PAPPA2 , which encode metalloproteinases that are known to be invo[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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