IndraLab

Statements

CYLD activates CYLD. 5 / 6
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"IKKβ also induces phosphorylation of CYLD at serine 568, subsequently activating CYLD’s deubiquitination function to terminate NF-κB signaling [4]."
37176077
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"Co-IP and GST results showed that KLHL21 directly interacted with CYLD in BC cells, and restrained the ubiquitination of CYLD, thereafter suppressing CYLD degradation."
36538852
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"Our previous research has demonstrated that adult T-cell leukemia/lymphoma (ATLL) had high level of CYLD phosphorylation, down-regulating CYLD phosphorylation could increase CYLD deubiquitinase activity and then promoted apoptosis in ATLL [XREF_BIBR]."
33827598
eidos
"Knockdown of CYLD leads to diminished CYLD and p18 fluorescence and consequent reduction in co-localization ( Fig. 5d ) ."
33654169
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"Treatment with MPA also increases the transcription of ubiquitin carboxyl-terminal hydrolase CYLD (log2FC 0.12, padj = 0.04), which is known to suppress the NF-κB, p38MAPK and c-Jun N-terminal kinase (JNK) cascades."
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