IndraLab

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USP46 deubiquitinates methane. 6 / 6
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"By reducing Arrow ubiquitylation and turnover, the Usp46 complex increases cell surface levels of Arrow and enhances the sensitivity of target cells to stimulation by the Wingless morphogen, thereby increasing the amplitude and spatial range of signaling responses."
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"By reducing Arrow/LRP6 ubiquitylation, the Usp46 complex increases Arrow/LRP6 stability and cell surface levels, thereby enhancing the sensitivity of target cells to Wingless stimulation."
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"We found that the Usp46 complex markedly decreased levels of ubiquitylated Arrow (Fig. 8A)."
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"Similarly, the Usp46 complex decreased endogenous levels of ubiquitylated Arrow in S2R+ cells (Fig. 8B)."
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"These results provide evidence that Arrow deubiquitylation by the Usp46 complex increases Arrow levels at the cell surface and thereby promotes Wingless signaling (Fig. 8D)."
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"By reducing Arrow/LRP6 ubiquitylation and turnover and thus increasing cell surface Arrow levels, Usp46 enhances the sensitivity of target cells to Wingless stimulation."
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