IndraLab

Statements

P14_3_3 binds KCNH2. 4 / 5
| 4
sparser
"A second level of β-AR/PKA regulation of HERG may occur with the association of adaptor proteins such as 14-3-3, which binds to HERG when the channel is phosphorylated and affects channel gating and duration of the response [ xref , xref ]."
22613764
sparser
"Thus, 14-3-3 interactions with hERG provide a unique mechanism for plasticity in the autonomic control of stress-dependent regulation of cardiac membrane excitability."
16050263
sparser
"The adaptor protein 14-3-3ℇ interacts with Kv11.1 in the NTD and CTD."
| PMC
sparser
"Thus, 14-3-3 interactions with HERG may provide a unique mechanism for plasticity in the control of membrane excitability and cardiac rhythm."
11953308