IndraLab

Statements

KCNH2 activates UPR. 4 / 4
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sparser
"Our results suggest that trafficking-deficient G572R-hERG and E637K-hERG mutant proteins can activate UPR and are targeted to the proteasome for degradation."
22242185
sparser
"Both mutant hERG proteins could activate the UPR by upregulating levels of active ATF6."
22242185
reach
"The accumulation of the misfolded or imperfectly folded hERG proteins could cause UPR, which is an endoplasmic reticulum stress response that promotes the generation of the chaperones and serves a vital role in the prevention of unfolded proteins accumulation [XREF_BIBR]."
28763460
reach
"These findings demonstrated that the hERG trafficking defect induced by DHB activates UPR."
28763460