IndraLab

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KCNH2 activates UPR. 4 / 4
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"The accumulation of the misfolded or imperfectly folded hERG proteins could cause UPR, which is an endoplasmic reticulum stress response that promotes the generation of the chaperones and serves a vital role in the prevention of unfolded proteins accumulation [XREF_BIBR]."
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"Both mutant hERG proteins could activate the UPR by upregulating levels of active ATF6."
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"Our results suggest that trafficking-deficient G572R-hERG and E637K-hERG mutant proteins can activate UPR and are targeted to the proteasome for degradation."
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"These findings demonstrated that the hERG trafficking defect induced by DHB activates UPR."
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