IndraLab

Statements

USP7 activates EZH2. 7 / 7
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"To further validate our findings, we tested whether USP7 specific inhibitor suppresses USP7 mediated stabilization of EZH2 protein."
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"USP7 could increase EZH2 level , which in turn inhibited TIMP2 expression via methylation in its promoter ."
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"Moreover, another research illustrated that USP7 elevates EZH2 stability by mediating EZH2 deubiquitination in prostate cancer cells [XREF_BIBR]."
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"XREF_BIBR Downregulation of USP7 promotes the stabilization of EZH2 protein."
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"Herein, we identified that EZH2 is a deubiquitination target of USP7 and that EZH2 protein stability is increased by USP7."
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"USP7 has been shown to induce prostate cancer cell migration and invasion by stabilizing the Enhancer of Zeste homolog 2 (EZH2) gene."
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"USP7 is able to enhance cancer cell invasiveness and proliferation by stabilizing EZH2, depending on its deubiquitination."
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