IndraLab

Statements

TDRD3 activates USP9X. 4 / 4
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"Furthermore, we found that one of the USP9X de-ubiquitination targets, myeloid cell leukemia protein 1, is regulated by TDRD3, indicating that TDRD3 potentially regulates USP9X de-ubiquitinase activity."
28101374
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"Although it has been reported that USP9X interacts with, deubiquitylates, and stabilizes TDRD3 and that USP9X is stimulated by TDRD3 , our study reveals that TOP3B is a substrate of USP9X and establishes that USP9X requires TDRD3 to deubiquitylate TOP3B."
37980342
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"This dynamic change was diminished in Tdrd3-null MEFs, suggesting that TDRD3 mediates USP9X SG localization (XREF_FIG)."
28101374
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"Knockdown TDRD3 inhibits the presence of USP9X in the structure of SGs and increases cellular apoptosis (Narayanan et al., 2017)."
34604242