IndraLab

Statements

USP49 activates CREBBP. 7 / 7
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"Moreover, USP49 knockdown also suppressed tumor and CBP resistance in vivo."
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"Therefore, USP49 promotes RB tumor growth and CBP resistance in vivo.3.4 USP49 promotes cell proliferation and CBP resistance in RB cells via autophagy activation."
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"Furthermore, we provide insights into the underlying mechanism by which USP49 mediates CBP resistance in RB through autophagy activation."
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"Rescue experiments confirmed the pivotal role of SIRT1 in USP49-mediated CBP resistance."
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"Interestingly, USP49 expression was elevated in CBP‐resistant RB cells compared to parental RB cells."
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"Overexpression of USP49 promoted cell proliferation, inhibited cell apoptosis, and increased the IC50 value of CBP in RB cells."
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"On the contrary, USP49 knockdown suppressed cell proliferation, increased cell apoptosis, and reduced the IC50 value of CBP in CBP‐resistant RB cells."
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