IndraLab

Statements

USP13 binds EIF5B. 3 / 3
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"USP13 interacts with eIF5B and negatively regulates its post-transcriptional expression."
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sparser
"First, USP13 binds to eIF5B and enhances its interaction with SQSTM1/P62, promoting autophagy-lysosomal degradation of eIF5B. Second, previous studies show the functions of USP13 in SQSTM1/P62–USP13 stabilizes SQSTM1/P62 through depubiquitination, thus promoting the oligomerization of SQSTM1/P62 [ xref ], augmenting SQSTM1/P62’s substrate recruitment."
41400714
sparser
"Co-immunoprecipitation and immunoblot analysis confirmed the interaction between exogenous USP13 and endogenous eIF5B in NRVMs, with similar observations in the HEK−293T cell line (Fig. xref C, E)."
41400714