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USP2 activates Colitis. 3 / 3
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"These data suggest that USP2 is upregulated in the inflamed colon tissues in DSS-treated mice and in UC patients.We next investigated the roles of USP2 in DSS-induced colitis in mice."
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"USP2 promotes experimental colitis and bacterial infections by inhibiting the proliferation of myeloid cells and remodeling the extracellular matrix network."
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"These data together suggest that knockout of USP2 increases myeloid cells in the lamina propria of mice after DSS treatment.We next sorted the RFP cells from the CD45 LPMCs of Lyz2-Cre;Ai14 and Lyz2-Cre;Usp2 Ai14 mice that were induced colitis and performed transcriptome sequencing assays (Fig. 2A)."
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