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Pyraclofos activates KCNQ5. 7 / 7
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"Tea polyphenols epicatechin gallate (ECG) and epigallocatechin-3-gallate (EGCG), but not epicatechin or epigallocatechin, isoform-selectively hyperpolarized KCNQ5 activation voltage dependence."
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"BMS-204352 potentiated the voltage activated KCNQ5 current at all potentials tested."
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"We also examined the effect of paroxetine on the voltage-dependent activation of Kv7.1, Kv7.4 and Kv7.5 channels at the concentrations near their IC values."
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"We also examined the effect of paroxetine on the voltage-dependent activation of Kv7.1, Kv7.4 and Kv7.5 channels at the concentrations near their IC 50 values."
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"Similarly, HN37 induces a rotamer change of the conserved Trp270 in S5, as well as slight motions of S5 and the adjacent S6 away from each other (), which may potentiate the activation of KCNQ5 by voltage and PIP 2 ."
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"To test this hypothesis, we studied effects of combinations of compounds each at 10 μM. Fresh EGCG could not induce KCNQ5 activation in combination with ECG (Fig. 10A–C), while at 10 μM heated EGCG caused a −7.1 ± 1.6 mV shift in KCNQ5 activation voltage dependence (Fig. 10D, E) and hyperpolarized E by −8.7 ± 2.5 mV (Fig. 10F)."
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"Strikingly, the combination of heated and fresh EGCG produced larger shifts, in both KCNQ5 activation voltage dependence (−10.4 ± 1.7 mV) (Fig. 10G, H) and E (−14.2 ± 2.0 mV) (Fig. 10I)."
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