IndraLab

Statements

CYLD decreases the amount of CXCL8. 10 / 10
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"Addition of CYLD siRNA to A20 siRNA further increased the IL-8 mRNA expression suggesting additive effects of CYLD and A20."
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"Addition of CYLD siRNA to A20 siRNA further increased the IL-8 mRNA expression in tolerant cells suggesting additive effects of CYLD and A20."
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"CYLD negatively regulates nontypeable Haemophilus influenzae induced IL-8 expression via phosphatase MKP-1-dependent inhibition of ERK."
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"Having demonstrated that CYLD suppresses NTHi induced IL-8 expression, we next aimed to investigate the mechanism through which this regulation occurs."
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"Together, these data suggest that CYLD negatively regulates IL-8 expression by specifically targeting the ERK signaling pathway."
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"We next sought to determine whether CYLD inhibits upregulation of IL-8 expression induced by direct activation of ERK using a constitutively active form of MEK (MEK-CA)."
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"In this study, we demonstrated that CYLD strongly suppressed NTHi induced IL-8 expression in human lung epithelial cells."
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"Importantly, we determined that CYLD negatively regulates ERK dependent IL-8 expression specifically by inducing MKP-1 expression."
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"Here, we show that CYLD suppresses NTHi induced IL-8 expression by specifically targeting the activation of ERK."
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"We further demonstrated that CYLD decreased IL-8 levels via inactivation of the ERK signaling pathway."
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