IndraLab

Statements

CYLD decreases the amount of CXCL8. 11 / 11
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"Importantly, we determined that CYLD negatively regulates ERK dependent IL-8 expression specifically by inducing MKP-1 expression."
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"Here, we show that CYLD suppresses NTHi induced IL-8 expression by specifically targeting the activation of ERK."
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"Addition of CYLD siRNA to A20 siRNA further increased the IL-8 mRNA expression in tolerant cells suggesting additive effects of CYLD and A20."
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"Addition of CYLD siRNA to A20 siRNA further increased the IL-8 mRNA expression suggesting additive effects of CYLD and A20."
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"We next sought to determine whether CYLD inhibits upregulation of IL-8 expression induced by direct activation of ERK using a constitutively active form of MEK (MEK-CA)."
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"We further demonstrated that CYLD decreased IL-8 levels via inactivation of the ERK signaling pathway."
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"CYLD negatively regulates nontypeable Haemophilus influenzae induced IL-8 Expression via phosphatase MKP-1-dependent inhibition of ERK."
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"In this study, we demonstrated that CYLD strongly suppressed NTHi induced IL-8 expression in human lung epithelial cells."
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"Blocking NF-ĸB pathway by JSH-23 attenuated the up-regulation of chemokines and pro-inflammatory cytokines induced by CYLD depletion, thereby suggesting that CYLD negatively regulates expression of CCL2, CCL5, CCL20, CXCL5, CXCL6, CXCL8, IL-6 and IL-1β via inhibition of NF-ĸB."
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"Together, these data suggest that CYLD negatively regulates IL-8 expression by specifically targeting the ERK signaling pathway."
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"Having demonstrated that CYLD suppresses NTHi induced IL-8 expression, we next aimed to investigate the mechanism through which this regulation occurs."
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