IndraLab

Statements


KITLG inhibits CYLD. 3 / 3
| 3

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"Altogether, these results support the model that CYLD degradation by SCF beta-TRCP plays a critical role in governing the timely activation of the NF-kappaB signaling pathway to control the osteoclast differentiation process (XREF_SUPPLEMENTARY)."

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"Taken together, these results indicated that SCF beta-TRCP might negatively regulate the protein stability of CYLD."

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"As IKK mediated phosphorylation of CYLD has been reported to negatively regulate CYLD enzymatic activity [XREF_BIBR], we further explored whether IKK is also involved in regulating the degradation of CYLD by SCF beta-TRCP."