IndraLab

Statements

KCNK2 inhibits BDNF. 3 / 3
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"Furthermore, overexpression of TREK-1 in astrocytes downregulated BDNF, and upregulated Bax and caspase-3, while TREK-1 shRNA effectively reversed the isoflurane dependent changes in BDNF, Bax and caspase-3 expression."
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"Overexpression of TREK-1 downregulates BDNF, and upregulates Bax and caspase-3."
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"We also found TREK-1 blockade could enhance the synthesis of BDNF in astrocytes, which might be important in neuroprotection [21]."
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