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USP19 activates YAP1. 3 / 3
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"Besides, ectopic expression of USP19 could increase YAP protein in a dose-dependent manner, while USP19 C506S lost the ability to increase YAP protein ( Fig. 1 G)."
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"For instance, the E3 ubiquitin ligases Fbxw7 and β-TrCP have been implicated in YAP1 ubiquitination and degradation in HCC [13, 14], while the deubiquitinase USP19 enhances YAP1 stability [15]."
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"Furthermore, as mentioned earlier, USP19 has a diverse range of substrates, and its activity is also influenced by multiple signaling pathways, highlighting its involvement in complex cellular process[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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