IndraLab

Statements

OTUD5 inhibits SYNM. 4 / 4
| 4
reach
"Besides, double‐immunofluorescence staining showed that OTUD5 in DA neurons of SN was significantly downregulated after α‐Syn PFF injection (Figure 5E)."
39721018
reach
"As there are physiological functions for α‐Syn, we investigated whether OTUD5 overexpression and knockout can perturb the cellular steady state by regulating α‐Syn."
39721018
reach
"Immunofluorescence also showed that OTUD5 deficiency upregulated the formation of pathologic p‐α‐Syn (Ser129) in TH‐positive neurons in SN (Figure 7B) and STR (Figure 7C)."
39721018
reach
"Notably, OTUD5 conditional deletion further increased pathological p‐α‐Syn induced by α‐Syn PFF (Figure  7A)."
39721018