IndraLab

Statements

OTUD5 inhibits SYNM. 4 / 4
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"As there are physiological functions for α‐Syn, we investigated whether OTUD5 overexpression and knockout can perturb the cellular steady state by regulating α‐Syn."
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"Besides, double‐immunofluorescence staining showed that OTUD5 in DA neurons of SN was significantly downregulated after α‐Syn PFF injection (Figure 5E)."
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"Immunofluorescence also showed that OTUD5 deficiency upregulated the formation of pathologic p‐α‐Syn (Ser129) in TH‐positive neurons in SN (Figure 7B) and STR (Figure 7C)."
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"Notably, OTUD5 conditional deletion further increased pathological p‐α‐Syn induced by α‐Syn PFF (Figure  7A)."
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