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USP14 decreases the amount of USP14. 7 / 7
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"USP14 siRNA effectively suppressed expression of USP14 without affecting that of off target protein, p38."
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"Notably, USP14 can also directly deubiquitinate and activate PI3K and lidocaine can inhibit the expression of USP14 and the activation of PI3K/AKT in HCC, and significantly inhibit the proliferation, [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Screening reveals that USP14 inhibits mitophagy and CRC (MSI-H) show high USP14 expression which correlates with poor prognosis."
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"Another example of neuroprotection was found in stroke, in which decreased expression of USP14 by microRNA or miR-124, as well as USP14 inactivation, was linked to neuron survival in the post-ischemic mouse brain 69."
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"Western blot analysis showed that the si-USP14 significantly reduced USP14 protein levels to 23.4% of the si-NC group (Fig. 3A)."
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"EPI suppressed the expressions of LC3II/I and TfR1, and increased the expression of USP14, which was significantly reversed by EPI + IU1 treatment, suggesting EPI inhibits autophagy via suppressing USP14 expression (Figure 7D)."
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"NLRC5 overexpression restored the decreased expression of NLRC5, p-Smad2, and p-Smad3 in USP14-depleted cells, but not affected USP14 expression (Fig. 6A&B)."
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