IndraLab

Statements

IL15 binds IL2RG. 20 / 22
1 1 | 14 6
reach
"In the absence of IL-15Ralpha, the beta and gammaC complex binds IL-15 with an intermediate affinity and is capable of mediating responses [XREF_BIBR]."
19818367
sparser
"These results strongly suggest that the gamma c chain transduces major signal(s) involved in NK cell differentiation from hematopoietic progenitor cells and that IL-15 interaction with gamma c is involved in this process at an earlier step than IL-2/IL-7 interactions of gamma c are."
8916956
reach
"Recently two modifications of IL-2 have been generated that block binding of normal IL-2 and IL-15 to IL-2 and IL-15Rbeta and gammac receptors, thereby simultaneously inhibiting the actions of both IL-2 and IL-15."
28182501
reach
"IL2, IL4, IL7, IL9, IL15, and IL21, all interact with the common gammac (IL2Rgamma) via the gammac box present in their D-helices 17."
31622625
reach
"At its site II interface, IL-15 binds to gamma c through a rather chemically ' featureless ' interface that stands in stark contrast to the highly polar and specific side chains contacts seen in the site I interface."
23104097
reach
"The binding of IL2 or IL15 to the IL2 and IL15Rbeta and gammac heterodimer induces JAK1 activation via the beta chain and JAK3 via the gamma chain that together phosphorylate tyrosine on the cytokine receptors and induce the tyrosine phosphorylation of STAT3, STAT5A and STAT5B that via SH2 domain interactions homodimerize, translocate to the nucleus and bind to regulatory regions of target genes."
25736261
reach
"Furthermore, IL-15 binds to gamma c with considerably lower shape complementarity than IL-2 or IL-4 (sc = 0.59 for IL-15 versus 0.84 for IL-2 and 0.82 for IL-4)."
23104097
sparser
"In contrast, IL-15 signaling is initiated by binding of IL-15 to the IL-15Rβ and γC molecules on the cell surface, which activates JAK1 and 3, followed by activation of STAT5 ( xref )."
27521337
reach
"Thus, cytokines other than IL-2, such as IL-15, which bind to IL-2Rbeta and gammac, are important for the development of NK, NK + alphabeta T and gammadelta T cells."
10817640
reach
"In EAE, the upregulation of IL2RG and other IL15 binding receptors is widespread."
26441851
reach
"IL-15Rbeta (also known as IL-2Rbeta or CD122) and IL-15Rgamma c (also known as CD132) can bind to both IL-15 and IL-2 with intermediate affinity."
29769573
reach
"IL-2 and IL-15 each bind the gamma (c) receptor (CD132), which signals through JAK1."
32536506
sparser
"Using an untargeted transcriptomic approach, we extricated signatures of chemokine-mediated T cell recruitment (CXCL10–CXCR3) and inflammation-dependent T cell activation (IL15–IL2RG, IL2RB), which we validated with targeted cytokine analyses."
38915597
sparser
"Additionally, we investigated ligand-receptor interactions through heatmap analysis (Fig.  xref G) and found significant differences in IL15-IL2RA, IL15-IL2RB, and IL15-IL2RG production by Treg cells."
39692961
sparser
"Among the cellular interactions between immune cells, macrophages interact with T cells via SPP1-CD44, CCL18-CCR8, ICAM1-ITGAL, SELPLG-SELL, ICAM1-AREG and HAVCR2-LGALS9, and DCs present strong potential interactions with T cells via the costimulator CD28/B7 family (CD86-CD28, CD86-CTLA4, ICOSLG-CD28, and ICOLG-CTLA4) and interleukin-15 (IL-15- IL-2RB and IL-15-IL-2RG)."
39543644
reach
"IL-15 shares many similarities to IL-2 as it also binds to CD122 and gammac."
25271022
reach
"IL-15 also binds to CD132/CD122 and its specific receptor IL-15Rα."
33482348
sparser
"All three tumor-enriched DC subsets showed strong potential interaction with Tex cells, proliferative T cells, and Treg cells via the co-stimulator CD28/B7 family (CD86-CD28, CD86-CTLA4, ICOSLG-CD28, [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31675496
reach
"These results strongly suggest that the gamma c chain transduces major signal (s) involved in NK cell differentiation from hematopoietic progenitor cells and that IL-15 interaction with gamma c is involved in this process at an earlier step than IL-2 and IL-7 interactions of gamma c are."
8916956
reach
"Thus, when IL-15/IL-15Rα binds to CD122 and CD132 on NK and T cells, it leads to enhanced durable cellular responses, including proliferation and cytotoxicity (11)."
38515757