IndraLab

Statements

Curcumin inhibits STAT1. 6 / 6
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"For example, curcumin suppressed STAT1 activation in murine dendritic cells and inhibited indoleamine 2,3-dioxygenase (IDO)-mediated suppression of T cell responses."
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"Among these, its anti-inflammatory effects are particularly notable, as curcumin suppresses inflammatory cytokines and chemokines via dose-dependent antioxidant mechanisms that downregulate key transcription factors, such as NF-κB, STAT-1, and STAT-3 [47,48,49]."
| PMC
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"Wang et al. further showed that curcumin decreases neuroinflammation in a model of intracerebral hemorrhage by inactivating the JAK1/STAT1 pathway in M1 microglia [38]."
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"Curcumin attenuates intracerebral hemorrhage-induced neuronal apoptosis and neuroinflammation by suppressing the JAK1/STAT1 pathway."
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"XREF_BIBR, XREF_BIBR, XREF_BIBR Curcumin has been shown to downregulate NAT activity and STAT1 activation (XREF_TABLE), thereby inhibiting cancer growth and inducing apoptosis in H1299 and A549 cells (XREF_FIG)."
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"Curcumin also suppresses Oncostatin M (a cytokine from interleukin 6 family) induced p-STAT1 [ 154 ]."
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