IndraLab
Statements
USP28 activates proteolysis. 4 / 4
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4
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"Overexpression of USP28 largely reversed HDAC5-KD-induced LSD1 protein degradation, suggesting a role of HDAC5 as a positive regulator of LSD1 through upregulation of USP28 protein."
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"Herein, we identified that USP28, a deubiquitinase aberrantly upregulated in patients with ADPKD, selectively removed K48-linked polyubiquitination and reversed protein degradation of signal transducer and activator of transcription 3 (STAT3)."
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"Overexpression of USP28 largely reversed HDAC5-knockdown-induced LSD1 protein degradation, suggesting HDAC5 positively regulates LSD1 by stabilizing USP28."
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"ATG7 promoted USP28 protein expression, which directly bound to and deubiquinated CD44s protein and inhibited CD44s protein degradation."