IndraLab

Statements

STAMBPL1 activates GRHL3. 3 / 3
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"In summary, STAMBPL1 promoted TNBC angiogenesis by activating the GRHL3/HIF1α/VEGFA pathway via interacting with FOXO1 in a non-enzymatic manner."
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"Our study reveals for the first time that GRHL3 promotes transcriptional activity by binding to the promoter of the HIF1A gene.In this study, we utilized two TNBC cell lines, HCC1806 and HCC1937, along with human primary umbilical vein endothelial cells (HUVECs) and a nude mouse breast orthotopic transplantation tumor model to investigate the regulatory mechanism by which STAMBPL1 activates the GRHL3/HIF1α/VEGFA signaling pathway through its interaction with FOXO1, thereby promoting angiogenesis in TNBC."
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"These findings suggest that STAMBPL1 activates the HIF1α/VEGFA axis by upregulating GRHL3."
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