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CALM activates SCN8A. 2 / 2
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"We have found that the GAC repeats in the 7th calmodulin like repeat in exon 13 represent a hot-spot for mutation, and that mutations in the 7th calmodulin like repeat produce severe PSACH phenotypes while mutations elsewhere in the gene exhibit mild PSACH or MED phenotypes."
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"Ca influx in the axonal initial segment can lead to a Ca ‐calmodulin modulation of Nav1.6 (Herzog et al., 2003) or to a Ca ‐induced Kv7 block (Martinello et al., 2015), in both cases increasing neuronal excitability and firing."
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