IndraLab

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ZDHHC2 binds USP19. 3 / 3
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"Next, the binding region of USP19 to ZDHHC2 was analyzed via molecular docking (Figure  xref ) and GST pull‐down assays (Figure  xref ), and we found that USP19 binds to the C‐terminal region of ZDHHC2."
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"Coimmunoprecipitation confirmed the endogenous interaction between ZDHHC2 and USP19 (Figure  xref ), GST pull‐down verified the direct physical interaction (Figure  xref ), and PLA further demonstrated spatial proximity interactions (Figure  xref )."
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"Given that ZDHHC2 regulates ACSL4 through USP19, we subsequently investigated the functional impact of the ZDHHC2‐USP19 axis on ferroptosis."
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