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TAK1 inhibitors activates USP29. 1 / 1
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"Moreover, TAK1 inhibitors abrogated the protective effect of USP29 on hepatic I/R injury, suggesting that the regulation of hepatic I/R injury by USP29 is dependent on the TAK1-JNK/p38 pathway.We used USP29 full knockout mice rather than hepatocyte-specific knockout mice, which may contain confounding effects of USP29 function in hepatic inflammatory cells."