IndraLab

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MiR-30b decreases the amount of SCN9A. 6 / 6
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"Both miR-30b and miR-182, highly expressed in NeuP developed post nerve injury, could reduce the amount of NaV1.7 and alleviate NeuP (Shao et al., 2016; Cai et al., 2018)."
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"Surprisingly, overexpression of miR-30b lowered the expression of Nav1.3, Nav1.6, and Nav1.7 both in DRG neurons and the spinal cord, which greatly reduced neuropathic pain brought on by SNL or oxaliplatin (Shao et al., 2016; Su et al., 2017; Li L. et al., 2019)."
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"We also observed that miR-30b decreased Nav1.7 expression in PC12 cells."
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"Our data indicate that miR-30b can inhibit Nav1.7 expression by preventing SCN9A transcription in DRGs."
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"Shao et al. demonstrated that both in vivo and in vitro, over-expression of miR-30b inhibited SCN9A transcription and decreased Nav1.7 expression, thereby resulting in pain relief [78] ."
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"Overexpression of miR-30b attenuates neuropathic pain by inhibiting Nav1.7 expression [37] ."
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