IndraLab

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Dapagliflozin inhibits NLRP3. 35 / 35
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"Interestingly, inhibition of the NLRP3 pathway was not observed in isolated macrophages treated with dapagliflozin."
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"Dapagliflozin attenuated the activation of Nlrp3/ASC inflammasome, fibrosis, and deterioration of left ventricular ejection fraction in diabetic BTBR ob/ob mice [45]."
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"Dapagliflozin reduced NLRP3/ASC inflammasome activation and activated AMPK both in vivo and in vitro."
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"Results of our study indicated that SGLT2 inhibitors dapagliflozin can attenuate the formation of atherosclerotic lesion and increase the stability of lesion by inhibiting the NLRP3 inflammasome in diabetic atherosclerosis, which provide further evidence for its benefits in DM patients"
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"Meanwhile, in the diabetic atherosclerosis model, dapagliflozin (1 mg/kg/day for 12 weeks via intragastric route) reduced the production of IL-1β, IL-18, NLRP-3 protein, and mitochondrial ROS in the m[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Ye et al. found that dapagliflozin inhibited NLRP3/ASC inflammasome and attenuated the development of DCM via AMPK activation ( Ye et al., 2017 )."
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"The results showed that dapagliflozin decreased the activation of the NLRP3 inflammasome pathway in the Dox-treated H9C2 cells."
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"Dapagliflozin was also found to inhibit the NLRP3 inflammasome, but the mechanism was likely mediated by activating AMPK (Ye et al., 2017) ."
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"Dapagliflozin has been seen to reverse the increased NLRP3, ASC, IL-1β, or caspase-1 in mice models with T2DM, which reflects increased NLRP3-inflammasome complex formation and risk for pyroptosis (a highly inflammatory type of programmed cell death)[79]."
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"Dapagliflozin applied prior to I/R in mice improved autophagic flux and reduced the activation of the NLRP3 system."
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"106 A study proved that dapagliflozin attenuated NLRP3 , ASC , IL1beta , IL6 , and caspase 1 , as well as TNFalpha mRNA levels , markedly through the activation of AMPK in hearts of diabetic mice ."
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"Ye et al. discovered that dapagliflozin reduces NLRP3/ASC activation in the hearts of DM mice [36] ."
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"Dapagliflozin, an SGLT-2 inhibitor, in a mouse model, has been shown to significantly decrease the activation of the NLRP3 inflammasome in DCD."
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"In parallel, dapagliflozin treatment decreased circulating levels of NLRP3, IL-1β, and IL-18, as well as in the abdominal aorta of ApoE mice with DM and atherosclerosis [44]."
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"Similarly, previous studies have evidenced that dapagliflozin down-regulated activation of Nlrp3/ASC and attenuated deterioration of diabetic cardiomyopathy and nephropathy in T2DM mice."
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"Dapagliflozin can attenuate cardiac remodeling, activation of the NLRP3 inflammasome, fibrotic activity, and LV impairment."
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"Treatment with dapagliflozin attenuated the activation of NLRP3 inflammasome especially in the animals with diabetes [58]."
| PMC
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"Interestingly, the addition of saxagliptin to dapagliflozin further reduced the activation of the NLRP3/ASC inflammasome in BTBR ob/ob T2DM mice [45]."
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"In addition, dapagliflozin was reported to inhibit the NLRP3 inflammasome, resulting in attenuation of fibrosis in diabetic mice (98)."
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"Moreover, dapagliflozin was only recently shown to inhibit the NLRP3 inflammasome, thereby enhancing the anti-inflammatory and anti-fibrotic changes in DKD."
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"This result indicated that cell membrane damage was attenuated when NLRP3 was inhibited and dapagliflozin might also reduce the membrane damage by inhibiting the activity of NLRP3."
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"Ticagrelor, a P2Y12 receptor antagonist, and dapagliflozin, a sodium-glucose-cotransporter-2 inhibitor, suppress the activation of the NLRP3 inflammasome."
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"Ye et al. demonstrated that dapagliflozin, an SGLT2 inhibitor, reduced NLRP3/ASC activation in samples of myocardial tissue in mice with T2D, slowing the progression of diabetic cardiomyopathy."
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"In addition, it has been found that dapagliflozin (DAPA), another DM2 agent, inhibits NLRP3 inflammasome [84]."
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"Dapagliflozin Can Inhibit the Assembly and Activation of NLRP3 Inflammasome."
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"Furthermore, a recent study found that dapagliflozin inhibited the NLRP3 inflammasome and activated AMPK, which protected against the progression of diabetic cardiomyopathy and cardiac fibrosis."
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"In the T2DM mouse model, the ob/ob mice, dapagliflozin improved left ventricular function, attenuated activation of the Nlrp3 inflammasome and reduced inflammatory mediators by an AMPK dependent mechanism."
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"Both dapagliflozin and ticagrelor attenuated the progression of diabetic cardiomyopathy, the activation of the NLRP3 inflammasome, and fibrosis in BTBR mice with additive effects of the combination."
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"The results indicated that dapagliflozin may inhibit NLRP3 activation in an animal model of PAH."
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"Dapagliflozin blocked the activation of the NLRP3 inflammasome by promoting the metabolite itaconate from the mitochondrial TCA cycle in the chronic fibrosis kidney in mice models."
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"These results suggested that dapagliflozin can reduce the ROS production and NLRP3 inflammasome activation in aortic root of the DM mice."
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"Dapagliflozin treatment reduced the production of NLRP3 protein and ROS in aortic tissues, thereby partially reversing the formation of atherosclerosis XREF_BIBR."
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"High-dose of dapagliflozin pretreatment may limit the activation of NLRP3 inflammasome and mediate its selective autophagy [37]."
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"Dapagliflozin also inhibited the activation of NLRP3 inflammasome by activating AMPK and mTORC2 XREF_BIBR, XREF_BIBR."
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"In addition , dapagliflozin suppresses NLRP3 activation by decreasing p38-dependent toll-like receptor 4 ( TLR4 ) expression ."
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