IndraLab

Statements

Dapagliflozin inhibits NLRP3. 14 / 14
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"In addition , dapagliflozin suppresses NLRP3 activation by decreasing p38-dependent toll-like receptor 4 ( TLR4 ) expression ."
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"Dapagliflozin can attenuate cardiac remodeling, activation of the NLRP3 inflammasome, fibrotic activity, and LV impairment."
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"Both dapagliflozin and ticagrelor attenuated the progression of diabetic cardiomyopathy, the activation of the NLRP3 inflammasome, and fibrosis in BTBR mice with additive effects of the combination."
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"106 A study proved that dapagliflozin attenuated NLRP3 , ASC , IL1beta , IL6 , and caspase 1 , as well as TNFalpha mRNA levels , markedly through the activation of AMPK in hearts of diabetic mice ."
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"In the T2DM mouse model, the ob/ob mice, dapagliflozin improved left ventricular function, attenuated activation of the Nlrp3 inflammasome and reduced inflammatory mediators by an AMPK dependent mechanism."
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"Dapagliflozin Can Inhibit the Assembly and Activation of NLRP3 Inflammasome."
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"Ticagrelor, a P2Y12 receptor antagonist, and dapagliflozin, a sodium-glucose-cotransporter-2 inhibitor, suppress the activation of the NLRP3 inflammasome."
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"These results suggested that dapagliflozin can reduce the ROS production and NLRP3 inflammasome activation in aortic root of the DM mice."
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"Dapagliflozin treatment reduced the production of NLRP3 protein and ROS in aortic tissues, thereby partially reversing the formation of atherosclerosis XREF_BIBR."
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"Dapagliflozin was also found to inhibit the NLRP3 inflammasome, but the mechanism was likely mediated by activating AMPK (Ye et al., 2017) ."
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"Results of our study indicated that SGLT2 inhibitors dapagliflozin can attenuate the formation of atherosclerotic lesion and increase the stability of lesion by inhibiting the NLRP3 inflammasome in diabetic atherosclerosis, which provide further evidence for its benefits in DM patients"
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"Dapagliflozin also inhibited the activation of NLRP3 inflammasome by activating AMPK and mTORC2 XREF_BIBR, XREF_BIBR."
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"Treatment with dapagliflozin attenuated the activation of NLRP3 inflammasome especially in the animals with diabetes [58]."
| PMC
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"Interestingly, inhibition of the NLRP3 pathway was not observed in isolated macrophages treated with dapagliflozin."
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