IndraLab

"18 Moreover, a reciprocal interaction between EZH2 and USP22 has been described in the sepsis‐induced myocardial dysfunction model: in this case, EZH2 represses USP22 through the H3K27me3 modification."

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"About the possible relationship among BMI1 , EZH2 , and USP22 , it has been reported that USP22 increases BMI1 : in gastric cancer, USP22 inactivation decreases the neoplasm growth, while high levels of BMI1 accelerate the cell cycle via INK4a/ARF and AKT. xref Moreover, a reciprocal interaction between EZH2 and USP22 has been described in the sepsis‐induced myocardial dysfunction model: in this case, EZH2 represses USP22 through the H3K27me3 modification. xref In acute myeloid leukemia, the activation of BAX and the inhibition of BCL2 lead to a reduced expression of BMI1 and EZH2 . xref Finally, both BMI1 and EZH2 seem to be targets for the same miRNA, the miR200 that is a key regulator of the epithelial‐mesenchymal transition; indeed, a reduced expression of these genes reduces the migration capacity of colon cancer cells. xref "

"The interaction between USP22 and EZH2 was further confirmed in HEK-293T cells transfected with Myc-tagged USP22 and Flag-tagged EZH2 ( xref )."

"Interestingly, IFN-γ also disrupted the interaction between USP22 and EZH2 after treatment with IFN-γ for only 15 minutes even before USP22 and EZH2 degraded ( xref )."

"We then generated USP22-truncated mutants and found that the C-terminus C19 peptidase domain, but not the N-terminal zinc finger–containing region, is sufficient to mediate USP22 interaction with EZH2 ( xref )."

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"Consistent with this, mutation of the critical cystines in the zinc finger structure did not affect USP22 interaction with EZH2 ( xref )."

"Consistent with our data that USP22 represses MHC-I expression through EZH2-mediated H3K27me3 at B2m and H2Kb promoters ( xref ), further real-time-PCR analysis confirmed that the USP22-EZH2 axis controls MHC-I expression at the mRNA level ( xref )."

"To further delineate underlying molecular mechanisms by which USP22 specifically controls EZH2 protein expression in tumor cells, we first determined whether USP22 interacts with EZH2."