IndraLab

"About the possible relationship among BMI1 , EZH2 , and USP22 , it has been reported that USP22 increases BMI1 : in gastric cancer, USP22 inactivation decreases the neoplasm growth, while high levels of BMI1 accelerate the cell cycle via INK4a/ARF and AKT. xref Moreover, a reciprocal interaction between EZH2 and USP22 has been described in the sepsis‐induced myocardial dysfunction model: in this case, EZH2 represses USP22 through the H3K27me3 modification. xref In acute myeloid leukemia, the activation of BAX and the inhibition of BCL2 lead to a reduced expression of BMI1 and EZH2 . xref Finally, both BMI1 and EZH2 seem to be targets for the same miRNA, the miR200 that is a key regulator of the epithelial‐mesenchymal transition; indeed, a reduced expression of these genes reduces the migration capacity of colon cancer cells. xref "

"18 Moreover, a reciprocal interaction between EZH2 and USP22 has been described in the sepsis‐induced myocardial dysfunction model: in this case, EZH2 represses USP22 through the H3K27me3 modification."