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COPS6 inhibits KITLG. 2 / 2
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"Furthermore, CSN6 has been found to decrease β-TrCP by promoting its autocatalytic degradation, thereby stabilizing SCF ubiquitin ligase substrate in colorectal cancer cells [22] ."

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"Study in colorectal cancer has found that up-regulation of CSN6 by EGF decreases SCF ubiquitin ligase substrate receptor β-transduction repeat-containing protein (β-TrCP) by promoting its autocatalyti[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"