IndraLab

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HDAC5 leads to the deubiquitination of USP28. 3 / 3
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"HDAC5 blocks USP28 polyubiquitination."
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"Additionally, belonging to class IIa HDACs, histone deacetylase 5 (HDAC5) attenuates the polyubiquitination of USP28 through its direct interaction with USP28, suggesting that HDAC5 has the ability to stabilize USP28 [54–56]."
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"Overexpression of HDAC5 significantly increases USP28 expression in cell lines and reduces USP28 polyubiquitination, supporting the idea that HDAC5 stabilizes LSD1 by enhancing its deubiquitinase prot[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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