IndraLab

Statements

Melatonin increases the amount of USP8. 2 / 2
| 2
reach
"The therapeutic effects of melatonin on endothelial dysfunction in sepsis were mediated by upregulating USP8 expression and inhibiting NICD degradation, maintaining the stability of Notch signaling."
37205094
reach
"Melatonin, however, upregulated USP8 expression, thus maintaining the stability of NICD and Notch signaling, which ultimately reduced EC injury in our sepsis model and elevated the survival rate of septic mice."
37205094