IndraLab

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CYLD inhibits transcription, DNA-templated. 6 / 6
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"In the search for the tumor suppressor function of CYLD, several laboratories reported that CYLD can inhibit the activation of the classical NF-kappaB p65 and p50 transcription factor (Trompouki et al[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"CYLD has deubiquitinating enzyme activity and inhibits the activation of transcription factor NF-kappaB."
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"The tumor suppressor gene CYLD, which was recently identified as the cylindromatosis gene, has a deubiquitinating enzyme (DUB) activity and inhibits activation of the transcription factor NF-kappaB, which has key roles in inflammation, immune responses, carcinogenesis, and protection against apoptosis [XREF_BIBR]."
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"CYLD, a tumor suppressor gene, has deubiquitinating enzyme activity and inhibits the activation of transcription factor NF-kappaB."
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"Consequently, CYLD inhibits the activation of the transcription factor NF-kappaB, which plays an important role for immune responses."
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"These observations suggest that suppression of CYLD enhances the activity of the IKK kinase and the nuclear localization of NF-kappaB transcription factors."
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