IndraLab

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USP1 activates apoptotic process. 6 / 7
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"Overexpression of USP1 promoted cell proliferation, apoptosis, migration and invasion, and decreased cell chemo-sensitivity; however, it could be partially reversed via the overexpression of miR-192-5p in osteosarcoma cell lines."
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"USP1 downregulation decreased expressions of fibrosis related genes, suppressed proliferation, and promoted apoptosis in TGF-beta1-induced LX-2 cells, which were reversed by SNAIL overexpression."
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"USP1 overexpression enhanced the migration and invasion of CRC cells, while its silencing attenuated the cell vitality and proliferation, induced the apoptosis of CRC cells."
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"Our data show that inhibition of USP1 efficiently blocked human beta-cell apoptosis without compromising function.Complex intracellular networks, namely, the DDR, monitor genome integrity and stabilit[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Knockdown of USP1 by siRNA decreased B-ALL cell growth and induced apoptosis."
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"Loss of Deubiquitinase USP1 Blocks Pancreatic beta-Cell Apoptosis by Inhibiting DNA Damage Response."
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