IndraLab

Statements

USP1 activates apoptotic process. 12 / 13
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"USP1 downregulation decreased expressions of fibrosis related genes, suppressed proliferation, and promoted apoptosis in TGF-beta1-induced LX-2 cells, which were reversed by SNAIL overexpression."
33926817
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"Overexpression of USP1 promoted cell proliferation, apoptosis, migration and invasion, and decreased cell chemo-sensitivity; however, it could be partially reversed via the overexpression of miR-192-5p in osteosarcoma cell lines."
29731868
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"Our data show that inhibition of USP1 efficiently blocked human β-cell apoptosis without compromising function."
30227958
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"In this study, we found that USP1 inhibition leads to the accumulation of polyubiquitinated proteins in HCC cells, triggers ER stress, and activates ATF4, and that silencing ATF4 can effectively block USP1-induced apoptosis and Noxa expression."
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"Furthermore, the abrogation of USP1 expression by shRNA knockdown induced apoptosis and autophagy in DLBCL cells and impaired the tumorigenic activity of these cells, which caused the reversion of chemotherapy resistance."
36352191
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"Knockdown of USP1 by siRNA decreased B-ALL cell growth and induced apoptosis."
33390793
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"USP1 overexpression enhanced the migration and invasion of CRC cells, while its silencing attenuated the cell vitality and proliferation, induced the apoptosis of CRC cells."
35579161
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"The results demonstrated that knocking down USP1 induced apoptosis in RL cells, but not in RL-4RH cells (Supplementary Fig. S2d, e), which is consistent with the previous report that RL-4RH cells were unable to undergo apoptosis due to loss of BAX/BAK expression [18]."
36352191
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"A significant increase in CHK1 levels and activity in tumor cells caused by the silencing of BRD7 enhances tumor cell sensitivity to CHK1 inhibitors, leading to increased cell death via apoptosis, which is reversed by the simultaneous knockdown of CHK1 or USP1."
37626049
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"These results suggest that the genetic inactivation of USP1 by siRNA silencing induces similar effects to those of ML-323 by promoting the apoptosis and autophagy of HCC cells."
36357365
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"Inhibition of USP1 induces both an increase in endogenous apoptosis and autophagy, triggers protective autophagy, and decreases apoptosis by causing an increase in AMPK phosphorylation,66 and the results may be either mutually reinforcing or antagonistic."
40083330
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"In various types of cancer, USP1 is often overexpressed and mediates the stabilization of inhibitors of DNA binding and cell differentiation (ID proteins family) to regulate tumor proliferation, metastasis and apoptosis [29]."
38366146