IndraLab

Statements

OTUB1 activates E2. 3 / 3
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"OTUB1 activates RIG-I via a dual mechanism ofK48 polyubiquitin hydrolysis and formation of an E2 and repressive complex with UBCH5c."
32023470
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"Recently, several studies have described a non canonical mode of OTUB1 action in which OTUB1 inhibits the ubiquitylation of target proteins by binding to and inhibiting the E2 ubiquitin conjugating enzyme UBE2N (also known as UBC13) independent of its catalytic activity XREF_BIBR XREF_BIBR XREF_BIBR XREF_BIBR."
24071738
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"This and other studies have reported that OTUB1 inhibits ubiquitylation by binding to and inhibiting E2 enzymes XREF_BIBR XREF_BIBR XREF_BIBR XREF_BIBR XREF_BIBR."
24071738