IndraLab

Statements



reach
"This and other studies have reported that OTUB1 inhibits ubiquitylation by binding to and inhibiting E2 enzymes XREF_BIBR XREF_BIBR XREF_BIBR XREF_BIBR XREF_BIBR."

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"TP53 is a central negative regulator of SLC7A11-mediated cystine uptake, together with nuclear factor E2-associated factor 2 (NRF2), interferon gamma (IFN-γ), and OUT domain-containing ubiquitin aldehyde-binding protein 1 (OTUB1) ."

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"Recently, several studies have described a non canonical mode of OTUB1 action in which OTUB1 inhibits the ubiquitylation of target proteins by binding to and inhibiting the E2 ubiquitin conjugating enzyme UBE2N (also known as UBC13) independent of its catalytic activity XREF_BIBR XREF_BIBR XREF_BIBR XREF_BIBR."