IndraLab

Statements

N-[3-[[5-iodo-4-[3-[[oxo(thiophen-2-yl)methyl]amino]propylamino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide inhibits IFNB1. 6 / 6
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"Although no differences in the production of transcripts were observed in the non treated cells, a difference was seen under infection conditions where both BX795 treated wild-type as well as TBK1 knockout cells produced significantly (p < 0.0001) lower amounts of IFN-alpha and IFN-beta transcripts compared to the mock treated cells."
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"In addition, BX795 inhibited the production of IFN-beta and TNF-alpha in DCs induced by DeltaN146 and LPS (XREF_FIG)."
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"Further analysis showed that BX795 effectively inhibited the induction of IFN-beta by DeltaN146 as measured by qRT-PCR (XREF_FIG)."
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"And the results of ELISA and western blot confirmed that BX795 and resveratrol were able to effectively inhibit the production of IFN-beta and inflammatory cytokines, respectively."
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"By contrast, BX795 significantly inhibited IFN-alpha and IFN-beta secretion but did not significantly affect the production of TNF-alpha, IL-6, MCP-1 and CXCL10."
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"We also recently reported that a BX795 treatment successfully inhibited IFN-beta production that was stimulated by the cytoplasmic delivery of cyclic di-GMP, an agonist for the DDX41 mediated STING-TBK1-IRF3 pathway in Raw 267.4 macrophage cells."
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