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Capsaicin decreases the amount of UCHL1. 3 / 3
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"In contrast to TRPV1 and SP, patients with IR did not show higher expression of TRPM8 (see also Keh et al 25) or higher NKA levels in nasal secretions.Regarding the therapeutic action of capsaicin, it[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"As the expression of the neuronal marker PGP9.5, decreased by capsaicin treatment, was significantly upregulated only in the W0 group (Fig. 2E, F, and Supplementary Fig. 2), it is plausible to suggest that restoring damaged neurons through TLR4 antagonist requires more time than inhibiting mast cell infiltration."
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"Higher doses of capsaicin caused complete loss of PGP 9.5 immunoreactive fibers in the epidermis and subepidermal plexus [45] Reinnervation of the epidermis began during the third and fourth weeks after the capsaicin injection."
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