IndraLab

Statements

Wnt activates USP46. 3 / 3
| 3
reach
"Wnt signaling promotes the binding of the USP46 complex to the Wnt coreceptor LRP6 at the cell surface, stabilizing LRP6 on the cell surface."
39329019
reach
"Wnt signaling induces the assembly of USP46, UAF1, and WDR20 into large cytoplasmic complexes but not into LRP6 signalosomes."
37798301
reach
"Thus, Wnt signaling induced a physical alteration of the USP46 complex in the cytoplasm.Because the association of the USP46 complex with LRP6 was enhanced in the presence of Wnt stimulation (Fig. 3E, F), we tested whether the USP46 complex interacted with LRP6 receptor aggregates in signalosomes that could be readily detected in sucrose density gradients ."
37798301