IndraLab

Statements

BAP1 decreases the amount of ATF3. 3 / 3
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"Hence, it is not surprising that BAP1 exhibited a prosurvival role and attenuated the metabolic stress-induced cell death by repressing the transcription of the activating transcription factor 3 (ATF3) and C/EBP homologous protein (CHOP) in a DUB activity-dependent manner [39]."
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"Considering that BAP1 inhibits transcription of ATF3 and CHOP genes by binding to their corresponding promoters , BAP1 downregulation in normal trophoblast differentiation may release ATF3 promotors from inhibition, thus contributing to trophoblast invasion."
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"BAP1 repressed glucose deprivation-induced ER stress cell death by inhibiting transcription of two major UPR-TFs, activating transcription factor 3 (ATF3) and C/EBP homologous protein (CHOP) (70)."
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