IndraLab

Statements


USP8 activates dopamine. 3 / 3
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"In brief, USP13 and USP8 promote α-Syn-related pathology, and the knockdown of USP13 and USP8 reduces α-Syn-induced DA neuronal death."

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"USP8 down-regulation completely prevented the loss of PINK1 KO DA neurons (XREF_FIG), restoring dopamine to wild-type levels (XREF_FIG)."

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"USP8 KD also prevented Parkin KO DA neurons loss and normalized mitochondrial morphological defects, although it did not ameliorate Parkin climbing performance (XREF_FIG)."