IndraLab

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BAP1 activates SLC7A11. 8 / 8
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"The FTO/BAP1 axis promoted MPP + -induced ferroptosis by suppressing SLC7A11."
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"The reduction of the tumor suppressor protein BAP1 and the ubiquitin ligase PRC1 of H2Aub can increase H2Aub uptake of SLC7A11 promoter [107]."
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"Several tumor-suppressors, such as p53 [69] , BAP1 [70] , and KEAP1 [71] , promote ferroptosis through inactivating SLC7A11, while some oncogenic signaling pathways such as PI3K-mTORC1 pathway have be[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Our data that BAP1 plays a role in regulating several metabolic pathways in osteoclasts also supports this concept.Repression of Slc7a11, the cystine/glutamate xCT amino acid antiporter that antagonizes glutamate metabolism in osteoclasts, is one mechanism by which BAP1 regulates such pathways ."
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"SLC7A11 is upregulated by BRCA1-associated protein 1 (BAP1) inactivation in cancer cells, which increases the uptake of cystine and the synthesis of GSH to develop the growth of cancer by inhibiting ferroptosis (Zhang et al. 2018)."
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"BAP1 can induce ferroptosis in a similar process to TP53 by downregulating SLC7A11 [57]."
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"In brief, according to their analyses, BAP1 inactivation leads to an up-regulation of the Solute Carrier family 7 member 11 ( SLC7A11 )."
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"It has been reported that the inactivation of BAP1 upregulates SLC7A11 and suppresses ferroptosis, resulting in tumor development."
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