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AKT inhibits USP8. 2 / 3
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"In the present study the linkage between PTEN loss, Akt activation, and USP8 levels and activity appeared to be somewhat different, and in our work Akt activation decreased, rather than enhanced, USP8 function by increasing USP8 ubiquitination and decreasing steady-state USP8 levels (data not shown)."
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"In fact, Akt activation has been shown to decrease USP8 function in glioblastoma cells (Panner et al., 2010), whereas in breast tumor cells Akt activation appears to lead to increased USP8 activity (Cao et al., 2007)."
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