IndraLab

Statements

RNF31 inhibits TNFAIP3. 3 / 3
| 3
eidos
"Mechanistic studies revealed that RNF31 was able to degrade A20 , which affected the inflammatory response and hepatocyte apoptosis mediated by the toll like receptor 4 ( TLR4 ) / myeloid differentiation factor88 ( MyD88 ) / nuclear transcription factor-kappaB ( NF-kappaB ) signaling pathway ."
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eidos
"In conclusion , RNF31 degrades A20 by ubiquitination and activates the TLR4 / MyD88 / NF-kappaB signaling pathway to aggravate acute liver injury ."
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"Actinomycin tracing and proteasome inhibition experiments showed that RNF31 degrades A20 through the proteasome pathway ."
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