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Statements

USP7 activates pyroptosis. 6 / 6
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"These data suggest that H2O2 induced ROS production , NLRP3 inflammasome activation , and pyroptosis by increasing USP7 ."
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"In addition, previous studies have indicated that USP7 can upregulate pyroptosis through several pathways, such as the USP7-SOX9-miR-96-5p-NLRP3 network in myocardial injury and cardiomyocyte pyroptosis [38], and the NOX4/NLRP3 pathway in H O -induced injury of chondrocytes [39]."
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"It is rational to hypothesize that USP7 may contribute to pyroptosis-induced COPD inflammation and mucus hypersecretion."
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"Depletion of USP7 abolished H O -mediated pyroptosis and ROS induction and inactivated NLRP3 inflammasome activation in rat chondrocytes (100)."
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"Suppression of NOX4 abrogated the function of USP7-mediated pyroptosis, ROS induction and NLRP3 activation in rat chondrocytes."
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"shUSP7 - or shNC-transduced chondrocytes were treated with either USP7 inhibitor ( P22077 , 5 muM ) or vehicle for 24 h , followed by administration of H2O2 ( 100 muM ) for 24 h. Flow cytometry results showed that H2O2 induced pyroptosis which was blocked by either USP7 KD or USP7 inhibitor ( Figure 2A ) ."
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