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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

USP7 activates pyroptosis. 2 / 2

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"These data suggest that H2O2 induced ROS production , NLRP3 inflammasome activation , and pyroptosis by increasing USP7 ."

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"shUSP7 - or shNC-transduced chondrocytes were treated with either USP7 inhibitor ( P22077 , 5 muM ) or vehicle for 24 h , followed by administration of H2O2 ( 100 muM ) for 24 h. Flow cytometry results showed that H2O2 induced pyroptosis which was blocked by either USP7 KD or USP7 inhibitor ( Figure 2A ) ."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...