IndraLab

Statements

USP7 activates pyroptosis. 2 / 2
| 2
eidos
"These data suggest that H2O2 induced ROS production , NLRP3 inflammasome activation , and pyroptosis by increasing USP7 ."
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eidos
"shUSP7 - or shNC-transduced chondrocytes were treated with either USP7 inhibitor ( P22077 , 5 muM ) or vehicle for 24 h , followed by administration of H2O2 ( 100 muM ) for 24 h. Flow cytometry results showed that H2O2 induced pyroptosis which was blocked by either USP7 KD or USP7 inhibitor ( Figure 2A ) ."
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