IndraLab

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Amodiaquine inhibits ACHE. 10 / 10
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"Amodiaquine and amopyroquine, with a phenyl substituent on the C(4)-amino group, were more potent inhibitors of electric eel AChE than chloroquine with an aliphatic substituent [ 10 ]."
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"Screening result -- Amodiaquine reactivates inhibited AChE."
26350723
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"This suggests that the inhibition of AChE by amodiaquine may involve binding of the protonated diethylamino and phenolic hydroxyl functions to the anionic and esteric sites of the enzyme respectively."
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"This suggests that the inhibition of AChE by amodiaquine may involve binding of the protonated diethylamino and phenolic hydroxyl functions to the anionic and esteric sites of the enzyme respectively."
7256355
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"Investigation of reversibility of AChE inhibition by amodiaquine was carried out as followed: 200 μL AChE (37 °C) were incubated with 2 μL amodiaquine (5 μM f."
26851641
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"Investigation of reversibility of AChE inhibition by amodiaquine was carried out as followed: 200 μL AChE (37 °C) were incubated with 2 μL amodiaquine (5 μM f.c."
26851641
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"The reversibility of AChE inhibition by amodiaquine was investigated by inhibiting AChE with 5 μM amodiaquine followed by extensive dilution (300-fold) and determination of enzyme activity."
26851641
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"In fact, incubation of OP-inhibited AChE with 100 μM amodiaquine resulted in a reduced apparent reactivation which was potentially due to the inhibition of reactivated AChE by the residual amodiaquine[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26851641
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"The reversibility of AChE inhibition by amodiaquine was investigated by inhibiting AChE with 5 μM amodiaquine followed by extensive dilution (300-fold) and determination of enzyme activity."
26851641
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"First, Katz and coworkers investigated the ability of the antimalarial drug amodiaquine and its analog ADOC to reactivate paraoxon-, sarin- and DFP inhibited human AChE and demonstrated reactivation by ADOC being superior compared to 2-PAM for all three OP."
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