IndraLab

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UCHL1 inhibits SNCA. 7 / 7
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"The mechanism of icariin may be related to upregulate Parkin and UCH-L1 expression in ubiquitin-proteasome system and HSP70 in molecular chaperone, thus enhancing the degradation of alpha-synuclein."
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"A previous study described that UCHL1 plays an important role in neurodegenerative diseases, and inhibition of UCHL1 by LDN caused the up regulation of the autophagic pathways and the clearance of alp[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"As an example, inhibition of UCHL-1 in rat ventral mesencephalic neurons induces intracellular alpha-synuclein aggregates (McNaught et al., 2002a)."
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"In addition, UCH-L1 inhibition by LDN-57444 treatment also enhanced cell-to-cell transmission of alpha-synuclein (XREF_FIG)."
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"Membrane associated UCH-L1 has been reported to promote alpha-syn neurotoxicity by possibly negatively regulating the lysosomal degradation of alpha-syn."
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"Severing UCHL1 from the membrane might increase degradation of alpha-synuclein, effectively reducing levels of this aggregation-prone protein and alleviating neuronal stress."
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"Severing UCHL1 from the membrane might increase the degradation of alpha-synuclein, effectively reducing levels of this aggregation-prone protein and alleviating neuronal stress."
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