IndraLab

Statements

UCHL1 inhibits SNCA. 6 / 6
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"Severing UCHL1 from the membrane might increase the degradation of alpha-synuclein, effectively reducing levels of this aggregation-prone protein and alleviating neuronal stress."
25191222
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"Membrane associated UCH-L1 has been reported to promote alpha-syn neurotoxicity by possibly negatively regulating the lysosomal degradation of alpha-syn."
25999815
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"As an example, inhibition of UCHL-1 in rat ventral mesencephalic neurons induces intracellular alpha-synuclein aggregates (McNaught et al., 2002a)."
16380264
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"In addition, UCH-L1 inhibition by LDN-57444 treatment also enhanced cell-to-cell transmission of alpha-synuclein (XREF_FIG)."
30429647
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"Severing UCHL1 from the membrane might increase degradation of alpha-synuclein, effectively reducing levels of this aggregation-prone protein and alleviating neuronal stress."
21704388
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"The mechanism of icariin may be related to upregulate Parkin and UCH-L1 expression in ubiquitin-proteasome system and HSP70 in molecular chaperone, thus enhancing the degradation of alpha-synuclein."
26169945