IndraLab

Statements

USP22 decreases the amount of SIRT1. 6 / 6
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"As shown in the data in Fig. 3 B, USP22-FLAG rather than USP22–C185S-FLAG could reduce the Sirt1 ubiquitination level, indicating that the USP22 plasmids functioned normally in the EMT model."
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"These results indicate that Rottlerin or Morusin is a potent USP22-specific small molecule inhibitor that downregulates Sirt1 and PD-L1 expression in HCT116 cells, which might be important for further[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In addition, USP22 could also decrease the acetylation of Ku70 by stabilizing the expression of Sirt1, thus inhibiting Bax mediated apoptosis and contributing to cisplatin resistance."
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"USP22 can reduce Ku70 acetylation by stabilizing SIRT1 expression, thereby inhibiting Bax-mediated apoptosis and promoting cisplatin resistance.ALDH1A3, a major ALDH isoenzyme, is important for the stem cell signature of lung cancer and is associated with enhanced cisplatin resistance in lung adenocarcinoma."
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"USP22 suppressed HG-induced ferroptosis in pancreatic beta cells by stabilizing SIRT1 expression."
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"Knockdown of endogenous USP22 in MV4-11 cells decreased SIRT1 protein levels (XREF_FIG) and significantly reduced cell growth (XREF_SUPPLEMENTARY)."
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