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USP22 decreases the amount of SIRT1. 2 / 2

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"In addition, USP22 could also decrease the acetylation of Ku70 by stabilizing the expression of Sirt1, thus inhibiting Bax mediated apoptosis and contributing to cisplatin resistance."

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"Knockdown of endogenous USP22 in MV4-11 cells decreased SIRT1 protein levels (XREF_FIG) and significantly reduced cell growth (XREF_SUPPLEMENTARY)."

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IndraLab

Statements

USP22 decreases the amount of SIRT1. 2 / 2

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