IndraLab

Statements

USP22 inhibits H2Bub1. 6 / 6
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"Western blot analysis of H2Bub1 abundance within asynchronous USP22 silenced and control cells indicates that USP22 silencing induces a moderate increase (1.1- to 1.5-fold) in the global abundance of H2Bub1."
33801331
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"In agreement with previous observations [49, 71], loss of USP22 expression in hIECs did indeed increase H2Bub1, a hallmark of transcriptionally active chromatin [72–74]."
35933402
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"We show that USP22 deficiency impairs H2Bub1 removal and induces chromatin compaction defects."
33801331
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"In addition, we reveal that USP22 deficiency impairs H2Bub1 removal in early mitosis and induces CIN."
33801331
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"Moreover, Usp22 knockout in mice corresponds with an overall increase in H2Bub1 abundance and enhances H2Bub1 accumulation in response to irradiation, which is associated with reduced γH2AX foci forma[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
34953650
reach
"Compared with Baohuoside I, treatment with Rottlerin or Morusin did not enhance USP22 depletion–induced H2Bub1 up regulation, PD-L1 and Sirt1 down regulation."
37769523